Antipsychotic Medication and QT Prolongation

Antipsychotic Medication and QT Prolongation

The QT interval represents ventricular depolarisation and repolarisation. Prolongation of this interval can lead to life-threatening complications. These can include arrhythmias such as Torsades de Pointes and Ventricular Fibrillation, which may ultimately lead to death. Many risk factors have been identified in prolonging the QT interval, one of which is medication commonly used in the treatme...

Medicines and QT Prolongation

Drug induced QT prolongation.

The drug-induced QT prolongation predisposes to development of torsades de pointes (TdP) ventricular tachycardia and sudden death. The association between specific drug and development of TdP is difficult to document, therefore, QT prolongation is considered as a surrogate marker of the proarrhythmia risk. Most of the drugs prolong QT interval usually by blocking the potassium IKr current or al...

QT prolongation due to roxithromycin.

Roxithromycin and other macrolide antimicrobials are widely used for a broad variety of infections such as upper respiratory tract infection and community acquired pneumonia. Prolongation of the QT interval, torsade de pointes polymorphic ventricular tachycardia, and sudden death are well described but little known adverse reactions common to all macrolides. We report the case of a 72 year old ...

Antipsychotic Medication and Risk of QTc Prolongation: Focus on Multiple Medication and Role of Cytochrome P450 Isoforms

Objective: To identify the effects of antipsychotics on QTc prolongation in light of age, gender, antipsychotic combination pattern, antipsychotic doses and cytochrome P450 (CYP) mediation, using large database describing the antipsychotic treatment of patients with schizophrenia in Japan. Methods: Using database of 4176 patients with schizophrenia discharged between April 2004 and March 2005 a...